DPRA: Direct Peptide Reactivity Assay test

Regulatory reference:	OECD 442C
Claim:	No-skin sensitizer and Hypoallergenic
Application field:	Substances or mixtures without metal compounds.
Description of the test:	The DPRA methods chemically quantifies (by LC-MS/MS or HPLC-UV) the covalent bonds of electrophilic chemical substances (oxidants, electron acceptors) to nucleophilic substances, as known to occur between allergens and skin proteins, in order to exclude the product’s activity in the related sensitization pathway.

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